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OOCYTE  ORIGINATE  FROM OVARIAN SURFACE EPITHELIUM –A NEW CONCEPT

Ghulam M ohyuddin.Wani DVM,PhD and Gazanfer Wani MB

ovarian surface epithelium

The ovarian germinal epithelium has not the special capacity to form new germ cells.The oocyte originates from the ovarian epithelium istead .Thus  ovarian surface epithelium assumes an importance. The new oocyte with zona pellucida and granulosa cells all originate from the surface epithelium.

  It means the human ovary could form primary follicles throughout the reproductive period. This opens a new window for reproductive medicine where the surface epithelium is regarded as the major source of ovarian cancers, and most of the neoplasms exhibit the histology resembling müllerian epithelia.

      With the differentiating capability of the surface epithelium, the histologic range of the neoplasms in this category may extend to include both germ cell tumors and sex cord-stromal cell tumors. Since the oogenic capability of ovarian surface cells has been proven, it is now believed that the oocytes can originate from them. The term “germinal epithelium”, hence, might become reductant.

    The Müllerian ducts differentiate after invagination of the coelomic mesothelium over the gonadal ridges during the 6th week of embryonic life.

           On the basis  of ovarian epithelium theory of follicle development  endometriosis can be explained. A three-dimensional culture system demonstrated that human ovarian surface epithelial cells exhibited a glandular-stromal structure when they were co-cultured with endometrial stromal cells in an estrogen-rich environment.

       Ovarian carcinomas in the epithelial-stromal category are thought to arise from the surface epithelium. The ovarian surface epithelium is physiologically involved in follicular rupture, oocyte release, and the subsequent repair of follicle wall during reproductive age. Simultaneously, ovulation may cause a loss of integrity of the surface epithelium, followed by accumulation of multiple mutations. The cortical invagination, surface stromal proliferation, and Müllerian differentiation of these cells are likely not to be an early step in the cancer development.

     Most epithelial ovarian carcinomas have been suggested to arise from the ovarian surface epithelium, which covers an ovary as a layer of flat to cuboidal cells. The epithelium is physiologically involved in follicular rupture and the subsequent repair of the follicle wall during reproductive age. Invagination and inclusion cysts are formed in the cortical stroma after cyclic ovulation. Consequently, ovulation may cause a loss of integrity of the surface epithelium followed by stepwise sequence of genetic alteration. Inclusion cysts are actually more common in ovaries

   Human ovarian surface epithelial cells exhibit a gland formation in co -culture with endometrial stromal cells in an estrogen-rich environment. The phenotypic plasticity of these cells shares a mesenchymal property when they are cultured on two layers of extracellular matrix and collagen gel. As  in vitro study of ovarian carcinogensis, several neoplastic cell lines were recently established from the surface epithelial cells of the human ovary.

Recently  in vitro culture of ovarian surface epithelium (OSE) and granulosa cells of humans, were investigated and a protocol  developed for the immortalization of each cell. The immortalized cell lines may supply us advanced studies on ovarian disorders as well as its physiological functions.

Ovarian granulosa cells play a key role in the functional maturation of the entire follicle. The molecular pathways in granulosa cells responsible for the growth, differentiation, and nursing the oocyte are still largely unknown.

Stem cells, with their unlimited self-renewal feature and their ability to differentiate into almost every mature cell type in the body, have enormous potential for research and therapeutic application.

sarah talaet paras wani
maryam-Talat-paras wani
gazanfer-mohyuddin-naseema wani

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When a woman is diagnosed with an ovarian cyst, it is most often a functional cyst and nothing to be alarmed about. They are harmless and usually resolve themselves in time. Complex cysts, on the other hand, are less common and require more serious attention.

An ovarian cyst occurs when the development and release of the egg during your monthly cycle does not occur in the usual fashion. The follicle that produces the hormones necessary to encourage the egg to release does not form properly. Fluid accumulates in the sealed off sac and becomes a cyst. They are known as “functional” cysts because they develop during a woman’s normal cycle.

A complex ovarian cyst is a cyst that is filled with both solid and liquid contents. There are three different types of complex cysts and each form in a different way. The symptoms and the treatment are also unique to each type.

Dermoid Cysts

A Dermoid cyst is a complex cyst that develops from the actual cells that create the egg and are therefore capable of developing the tissue that makes up the human body. As a result, a Dermoid cyst can contain skin, hair and teeth in addition to the normal that is usually part of a cyst. These cysts are almost never cancerous but they can be extremely painful and grow quite large.

Endometrioma

Endometriosis is a condition where the uterine cells grow outside of the uterus. An endometrioma is a type of complex cyst that often develops as a result of endometriosis where the uterine cells form a growth that attaches to an ovary. Controlling the endometriosis can sometimes also minimize the growth of cysts.

Cystadenomas

Cystadenomas is a complex cyst that forms on the surface of the ovary. It is filled with mucous and liquid and can grow extremely large. It can cause your ovary to twist and cause severe pain. They are generally benign.

Symptoms of Complex Cysts

Complex cysts can go unnoticed unless it is a very large cyst. It is sometimes misdiagnosed as the symptoms are similar to other conditions such as an ectopic pregnancy or endometriosis.

One of the most common symptoms of a cyst is an irregular menstrual cycle. Pain in the pelvic region that may radiate into the buttocks and thighs is another symptom.

There may be extreme pain during intercourse and right before menstruation begins. Sometimes the symptoms may be similar to the symptoms of pregnancy. Tender breasts, nausea, vomiting and a heavy feeling in the abdomen are all symptoms of a cyst.

Treatment Options for Complex Cysts

The most common traditional treatment for a complex cyst is surgery. It is generally recommended both to relieve discomfort and to perform a biopsy on the tissue. Even though complex cysts are not typically cancerous they are an instance of abnormal tissue growth and traditional medical practice is to perform a test to rule it out.

Even though a cyst of any type should be evaluated by your doctor a holistic approach to treating complex cysts can be extremely beneficial. It speeds healing before and after surgery and can help eliminate a future recurrance of a complex cyst.

Receiving a diagnosis that you have a complex cyst is often very unsettling. Taking positive countermeasures on your own can help you regain a sense of control over the situation. There are many positive holistic treatments you can undertake at home on your own that will work well in conjunction with the recommendations of your physician.

For more information on a holistic approach to eliminate the pain and discomfort of a complex cysts you can learn more about natural remedies to get rid of your cysts holistically, and often for good by visiting http://www.ovarian-cysts-treatment.info

Karen Kalata is an avid reader and writer and enjoys sharing resources that have helped her improve her life. In doing so, she has created relationships with certain experts and in recommending their products may receive compensation for doing so.

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Living life with painful ovarian cysts is like being on a roller coaster. One moment you are feeling fine and then all of a sudden you are struck with an acute sharp pain that feels like a knife being inserted into your body and slowly twisted. You want to live a normal life like your friends and work and play as they do, but the pain wears you down and leaves you feeling miserable and wretched. You are sick and tired of visiting the doctor, only to be told to wait another month and carry on taking the pills.

No one knows for sure what causes ovarian cysts but they are thought to be a result of hormonal imbalance and possible insulin resistance. Conventional medicine is only able to treat any current cysts and symptoms but cannot guarantee that the cysts, once removed, will not come back again. Holistic treatments, on the other hand, work with the body by getting to the core of the problem by cleansing the system and helping to bring the hormones back into line once more.

Excessive toxins in the body are one of the reasons that the body’s natural hormones become unbalanced, leading to problems in the menstrual cycle and the development and growth of painful ovarian cysts that would normally disappear on their own. These toxins accumulate in our bodies through daily exposure to products such as detergents, cleaning fluids, insecticides from chemicals to stop bugs that are sprayed onto the fruit and vegetables that we buy, hormones, steroids and antibiotics that are all present in non-organic produce, not to mention all of the manufactured chemicals that are present in food additives.

The easiest way to rid our bodies of these toxins is by doing a detox to flush everything out and give the body a kick start before embarking on a healthier lifestyle. The first part of the body to detox is the bowel since constipation and a back up of waste in the colon can cause untold pressure on an already bloated and inflamed abdomen, pressing down on the ovaries and causing considerable pain. You can take a fibre supplement but also incorporate plenty of fresh fruit and vegetables into your diet, using organic wherever possible and avoid red meat, alcohol, caffeine, wheat and dairy products. Foods such as carrot juice, beetroots, watercress,  and super foods such as wheatgrass and barleygrass, garlic, lemon juice and nuts and seeds are all great foods to be taken at this time. Be sure to incorporate plenty of water and herbal teas at this time as well but be sure to avoid sugar or artificial sweeteners. The aim of this exercise is to improve bowel efficiency so you are having regular bowel movements of at least once a day, or more ideally. Continue for about 10 days and once the bowels are regular you can concentrate on other areas.

Herbal supplements such as milk thistle work very well at cleansing the rest of the body and so do detox teas. Weekly salt baths also act as a very good aid to detoxing the body and most salts sold over the counter contain beneficial essential oils and vitamin supplements.

Whilst there are a great many detoxing resources and complex systems on sale on the internet and it is easy to spend a heap of money on such programmes, the truth is that it is best to work with your body and to do what feels right for you. Quite often all that is needed is plenty of water, fresh fruit and vegetables to correct the balance of natural hormones and toxins in your body. Remember, a healthy body is far less likely to develop disease or conditions such as painful ovarian cysts.

So many women are led to believe that medication or surgery are their only options but trust me when I tell you that natural treatments can and do work.

You no longer have to live with the pain, bloated stomach and feeling of nausea that are all symptoms of an ovarian cyst. Instead you can learn the remedies you can implement yourself to successfully shrink the cyst and prevent it from ever coming back simply by visiting
www.ovariancystremedies.info

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Are you the unfortunate individual who, while pregnant, believes that you are suffering from ovarian cysts?   Besides the normal physical toll placed on your body while carrying the fetus, an ovarian cyst(s) only adds to the discomfort and pain.  You seek relief from the discomfort.  You also may be concerned with how this condition will affect the birthing process.  With regards to ovarian cysts during pregnancy, there is important information about what is available in treatment.

First of all, it is not uncommon for women to have ovarian cysts while pregnant.  In order to confirm the presence of a cyst, your doctor will perform an ultrasound.  This procedure allows the physician to look at the size and shape of the cyst.  The good news concerning ovarian cysts, are two-fold.  First, most cysts statistically are found to be benign, (or non-cancerous).  Secondly, most cysts dissolve naturally on their own without surgical intervention.  Still, an ovarian cyst can be quite painful, which is not good for both the mother and her fetus.

The traditional methods involving treatment for ovarian cysts have involved either prescription medication, or a surgical procedure known as a laparoscopy.  If you are pregnant and have been diagnosed with an ovarian cyst, naturally your doctor would not prescribe medication, (usually hormonal or birth control pills).  As an alternative cure, your doctor may then suggest the laparoscopy.  This procedure involves an incision made on your naval.  From there, a small instrument is inserted into the incision to remove the cyst.  You may be asking how late in the birthing process can this procedure be performed without endangering the fetus, or mother.  Some doctors believe that it would be okay to perform this operation during the 2nd trimester in the woman’s birthing process.

Regarding this surgical procedure however, lately many women are opting not to have this invasive procedure performed.  Who can blame them?  The stress placed on both the individual and fetus during the procedure could result in medical complications.  Besides, while the cyst would be removed through this procedure, there can be no guarantee that another cyst would not re-develop in the woman’s ovaries at any future point.  So, what is the best solution to this problem, you may be asking?

Lately, many pregnant women who have developed cysts in their ovaries are turning to natural treatment procedures to eliminate this condition.  Not only are these natural (or holistic) cures proven to be highly successful at dissolving cysts.  But, as opposed to the traditional methods involving either surgery or a long term reliance on medication, these natural cures have statistically proven to be better at preventing cysts from recurring.

Reducing bladder pressure and increasing the amount of fiber in one’s diet are two natural treatment methods that have proven to be successful in dissolving ovarian cysts.  Drink at least 8 full glasses of purified or filtered water to flush out the toxins, (or bad chemicals) present within the body.  Drink warm herbal tea, as the ingredients in this drink contain plenty of anti-oxidants.  This will also flush out the toxins in one’s system.  Quality herbal tea has also been proven to relax both the mind and body.  

A diet high in fiber helps the body’s digestive process.  Fiber can be found in many quality breakfast cereals, in granola bars, beans, leafy vegetables, and in many fresh fruits.  Within your everyday diet, you should seriously consider cutting back on fat, sodium, and sugar anyway.  The chemical content in these ingredients are filled with bad chemicals, essentially poisonous to one’s body.  Think of not only your health, but the health of the child that you are carrying whenever you put food into your mouth.

Regarding ovarian cysts while pregnant, reducing the level of stress should be emphasized in your daily life.  Consider taking a long, warm, soothing bath to relax your mind and to help relieve the pain that comes with the presence of a cyst.  Get involved with relaxation exercises or meditation to relieve your mind and body as well.  Now that you have read this article, I am sure that you want more information.  Please visit this site: http://curesforovariancyst57.info to find out more about what you can do.  There are treatment plans available if you are pregnant and are suffer from the condition in having cyst(s) present in your ovaries.

Jefferson is very much concerned with health issues and enjoys sharing resources that have helped others.  In doing so, he has created relationships with certain experts.  In recommending their products he may receive compensation for doing so.

I am an individual who cares deeply about health and natural products designed to benefit and extend human life. I have had various health ailments effect both sides of my family in previous generations. My goal is to make readers aware of benefits that would lead them towards having healthier, longer lives

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What some people don’t realize is that ovarian cysts will continue to form until certain biological changes are made.  These don’t have to be major changes, it can even be something as small as cutting caffeine out of the diet.  The pain of living with ovarian cysts on a daily basis is enough to drive women insane, not to mention what it does to the physical appearance of the body.

Even though women try different medications many rarely find relief.  That’s where the natural cures come in.  There are methods and procedures that have been tried by others and actually found to work!

 The key is finding out what is causing the ovarian cysts, sometimes it’s an insulin imbalance or exposure to certain toxins.
By taking a systematic approach and making healthier choices in daily life, it’s much easier to get the relief a person needs.

  Sitting there and doing nothing about your ovarian cysts will not only continue the pain cycle, but it could leave you with some long lasting health problems.  Don’t risk developing more serious issues because of your ovarian cysts, get started today on a natural treatment plan that will keep you healthy and pain free for years to come.

When I had my own problems with my cysts, I was desperate to find a natural cure and get rid of the terrible pain. You can free yourself from the pain and get a natural cure to help you feel better right now.

Discover how thousands of women have instantly releived their constant pain and begin shrinking their Ovarian Cyst within 3 days, completely eliminating them within 8 weeks. This can be done without ever using drugs or resorting to risky surgery. Get help now with Natural Cure for Ovarian Cysts Home Remedy That Works!

Laura Madison is a health advocate for women’s issues and has been studying natural cures for women’s health issues for years.http://ovariancystcuresnow.info

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Ovarian cysts are very painful and you know this firsthand. You hate the way that your body feels and all you want is for it to go away. You want life to go back to normal but you don’t know where to even begin. You need to know how to get rid of this ovarian cyst pain and fast.

Surgery is a common option for a lot of women because this is how you are going to get rid of this cyst for good. The surgeon will remove the cyst from your body and you won’t feel the pain anymore. However, this procedure is very expensive and a lot of women can’t afford it, including you. You need a better way to get rid of this ovarian cyst pain.

In order to make this happen, there are some things that you can do. Heat is a great way to get rid of this pain and for good. Simply apply a hot towel or warm compress to your lower abdomen and let it do all of the work for you. You will notice that this heat will reduce cramping, soothe tense muscles and get rid of that pain. Plus, it works to increase circulation to the cyst, which actually helps to break it down. Using heat is a great way to get rid of ovarian cyst pain and will be something that you will want to try.

Use heat today so you can get rid of some of this pain and get your life back. You don’t have to be a victim anymore and you can find the relief that you have been desperate to have.

Many women suffer with ovarian cysts at some point in their lives. If you decide to pursue the traditional route of treatment be prepared to take medications or undergo surgery. There are natural ways to shrink and even destroy the cyst. Find out from this helpful site what you can be doing at home to remedy this condition.

You no longer have to live with the pain, bloating and weight gain that comes with having an ovarian cyst. If it’s impacting your life, it’s time to make a change. There is help and it’s all natural and effective. You can be rid of your ovarian cyst without surgery.

Article Source:http://www.articlesbase.com/women’s-health-articles/how-to-get-rid-of-ovarian-cyst-pain-1631965.html

I am sure that you can attest to the fact that we all seem to over complicate things at times. And when modern medicine decides that we have something wrong with us, well…that just make matters worse.

So, if you have some of the ovarian cyst symptoms, whether it is an official diagnosis from your doctor, or a self diagnosis…you will want to pay attention to every word of this article.

You see, both the medical community and the big pharmaceutical companies have a vested interest in our diagnosis AND our treatment. You are smart enough to see that, I am sure. They will schedule appointment after appointment, and prescribe one medication after another…each with potentially deadly side effects, I might add.

And then, if all of their so-called ‘treatments’ fail to make the cyst disappear…they will suggest that you have your ovarian cyst surgically removed. Again, the profits continue to climb for the physician(and the ‘team’)…and your bills as well as your frustration will soar. (if you are anything like me)

I seriously doubt that you will be told that after having the surgery and everything else that you went through…with modern medicines conventional methods…the cyst is very likely going to recur. Can you believe that?

So then, what are you supposed to do?

Would you like to learn about some proven NATURAL remedies that will totally eliminate your ovarian cyst, as well as all of the symptoms that are associated with them?

I will give you a few free pointers to help you out, but these are really just the tip of the iceberg, so to speak.

~ chamomile tea…helps with many different health problems and it will help you to relax so that you can sleep
~ processed food…filled with lots of sugar! You do not need to look far to find this, do you? But, if you eliminate these types of food, you are already on the road to better health.
~ a heating pad on the low setting will relieve some of the pain and discomfort associated with an ovarian cyst

If you want to learn more about some of the simple secrets that you can do at home, things like…’even if your doctor tells you to do this…NEVER do it’ OR…’an ingredient in your makeup is a common factor of ovarian cysts…find out what it is’… then, you will want to check into natural remedies to cure your ovarian cyst.

You owe it to yourself to investigate every possible treatment option before making a decision…it is your health…and natural treatments may just save your life!

So, your doctor wants to treat your ovarian cyst with medication and/or surgery…is that what YOU want? I hate to admit it, but I blindly followed my gynecologist’s advice…and after all of it…the cysts returned! Don’t make the same mistakes I made…try a natural remedy for ovarian cysts…first! http://Naturally-Cure-Ovarian-Cysts.info

Article Source:http://www.articlesbase.com/women’s-health-articles/surprisingly-simple-ways-to-eliminate-painful-ovarian-cyst-symptoms-all-natural-treatments-1623082.html

Surgery is commonly used as cure for ovarian cyst, but surgery is not the finest solution to this problem. First, problems may arise during the operation and secondly, surgery can’t stop new cysts from growing again. To know why surgery is not the best cure, you should to know first what ovarian cyst is & how it develops. The whole problem revolves around to its formation.

These are small sacs filled with liquid found in the ovaries of women. They form naturally during ovulation period, when a woman is about to release eggs for fertilization. Normally eggs dissolve after a few days or so, but some don’t and are filled with fluid or blood, eventually leading to ovarian cyst pain. There are different types of cysts: corpus luteum cyst, follicular cyst, hemorrhagic cyst, endometrioid cyst, dermoid cyst, cystandenoma and polycystic-appearing ovary PCOS.

Do you know that all these cysts can be treated naturally and it’s actually been around for a long time? Think about it, women of all ages have been facing ovarian cysts for centuries & you can bet that they must have found ways to naturally ease the pain.

Using the cures that nature provides is not only cheaper; it’s easier on the body. One of the things that you can do straight away to relieve some of the cyst pain is to take pressure off of your bladder. It may sound impractical but you would be surprised at how much cyst pain can be generated just because of surplus weight sitting on your bladder. Drink lots of water and go to the washroom frequently.

Another natural treatment for ovarian cyst is good old fashioned fiber. Constipation can never be fun, and just like extra pressure on your bladder causes discomfort, having a backed up colon will cause you major pain. Constipation in reality can worsen an ovarian cyst, so to avoid this try getting as much fiber intake as feasible. Great sources of fiber that your body can simply digest are found in vegetables and fruits.

Try eating foods such as pears, apples, barley, blueberries, oatmeal, beans and peas as often as you can. Teas are also a great way of getting antioxidants and nutrients into the body, which will flush out toxins and help you cure ovarian cyst. A lot of people will suggest you go & opt for surgery, but surgery of ovarian cyst is not the only option left. Ovarian cyst pain can be treated naturally.

So many women believe that surgery is the only options, but curing true root cause using a natural cure for ovarian cysts gives your body what it needs to dissolve your Ovarian Cyst safely and quickly eliminate all the pain. Learn the natural remedies and apply yourself to enjoy a life free from Cyst Pain simply by visiting http://www.NaturalCureForOvarianCyst.info

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Ovarian cysts are common developments in women. Women between the ages of 18 and 55 can develop these tiny cysts and there is no escape from them. You need to learn the signs and symptoms of an ovarian cyst so you can protect yourself and so you know how to treat it.

The biggest indication of an ovarian cyst is the pain. The pain that a woman feels from an ovarian cyst is unlike anything else. This pain is sharp, sudden and is strong enough to bring a woman to tears. A lot of women may think that they know what the pain is like and may think that it is similar to the pain of menstrual cramps but it absolutely is not. If you are experiencing super sharp pain in your abdomen, then you may have an ovarian cyst.

You need to know how to treat your cyst and to finally get relief. This pain is unbearable and you need some help. A great treatment for your ovarian cyst is heat. Heat is a great healer because it works with your body. Use a hot compress or a warm towel to give your body some relief from the pain. Almost instantly you will feel the heat working to soothe your tense muscles and get rid of your cramps. As well, the heat will work to promote circulation to the area, which will help to heal your cyst. The circulation of blood flow helps to bring fresh new blood to your cyst, which helps to naturally break it down. You will notice a big difference in the way that you feel.

Use these tips to self diagnose yourself and to treat your ovarian cyst today.

Many women suffer with ovarian cysts at some point in their lives. If you decide to pursue the traditional route of treatment be prepared to take medications or undergo surgery. There are natural ways to shrink and even destroy the cyst. Find out from this helpful site what you can be doing at home to remedy this condition.

You no longer have to live with the pain, bloating and weight gain that comes with having an ovarian cyst. If it’s impacting your life, it’s time to make a change. There is help and it’s all natural and effective. You can be rid of your ovarian cyst without surgery.

Article Source:http://www.articlesbase.com/women’s-health-articles/ovarian-cyst-symptoms-and-treatment-1619580.html

As you read every word of this article you begin to realize that the medical community, along with the major pharmaceutical companies would be in the position to lose an awful lot of revenue if we would just stand up for ourselves and tell them that we are tired of being pumped full of their deadly drugs and sliced open whenever they attempt to ‘cure us’.

You will probably become as outraged as I was when I learned that over ninety five percent of all woman with an ovarian cyst who are treated with conventional methods…need to have ovarian cyst surgery. You know, we have come so far in modern medicine, they offer us…the ‘wait and see’ treatment, the ‘throw some medication your way’ option or the ‘jab it with a needle to drain it’ method. Then, after spending time and money on what the doctor would lead you to believe ‘needed to be done’…they tell you that you require surgery.

But…do you really? Is that your only option to treat ovarian cyst symptoms?

Absolutely not!

Here is the bottom line…if you were to totally eliminate your cysts on ovaries using a natural treatment, that you could do right from your home…you would NOT be handing over your hard earned money to the doctors…time and time again! Yes…that is another downside of traditional medicine…the cyst will more than likely return.

Stop the madness…

If you could get your hands on a natural remedy for ovarian cysts that guarantees it will not only reverse and eliminate existing cysts on ovaries…and all of the severe pain that is associated with them, but will prevent any future cysts from forming…would you be interested?

Before you make the mistake of allowing your gynecologist to decide what treatment is ‘right for YOU’…try the Natural Ovarian Cyst Relief Secrets System…it delivers on its promises!

So, your doctor wants to treat your ovarian cyst with medication and/or surgery…is that what YOU want? I hate to admit it, but I blindly followed my gynecologist’s advice…and after all of it…the cysts returned! Don’t make the same mistakes I made…try a natural remedy for ovarian cysts…first! http://Naturally-Cure-Ovarian-Cysts.info

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