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Based upon recent clinical research findings, Vitamin D is the only remaining vitamin that may have significant cancer and cardiovascular disease prevention properties. Recent large-scale prospective randomized clinical research trials have not only failed to identify a cancer prevention role (beyond a healthy balanced diet) for Vitamin E, Vitamin C, folate, and beta-carotene (a member of the Vitamin A family) supplements, but data from these trials have strongly suggested an increased risk of adverse health outcomes, at least in some sub-groups of patients, with supplements of several of these vitamins.

Alas, as is typically the case with public health studies, the clinical data regarding Vitamin D is not without inconsistency, and the data on Vitamin D and cancer incidence has not been uniformly positive, either. However, multiple recent epidemiological and prospective clinical research studies have at least suggested that low levels of Vitamin D in our bodies may, in fact, be associated with a higher risk of developing certain cancers (look for a more comprehensive review of the data on Vitamin D and cancer prevention in my forthcoming book, “A Cancer Prevention Guide for the Human Race”).

Moreover, decreased blood levels of Vitamin D also appear to be linked to an increased risk of cardiovascular disease as well.

Now, a newly published prospective clinical research trial suggests that decreased levels of Vitamin D in the blood appears to be associated with an increased risk of breast cancer recurrence, and death due to breast cancer, in women previously diagnosed with early stage breast cancer. In this study, which has just been published in the Journal of Clinical Oncology, 512 women with early-stage breast cancer, diagnosed between 1989 and 1996, were prospectively followed for an average of nearly 12 years.

Blood was routinely collected from all women following their diagnosis of breast cancer, as a part of this clinical research trial. The women were then closely followed for recurrence of their breast cancer, and for death due to breast cancer and other causes.

As with other similar studies, a surprisingly large number of these otherwise healthy women were discovered to have decreased levels of Vitamin D in their blood. In 38 percent of these women, Vitamin D levels were significantly below normal levels, while another 39 percent of these women had mildly decreased levels of circulating Vitamin D. Among these 512 women, 116 experienced metastatic recurrence of their breast cancer during the course of this prospective clinical study, while 87 women died with evidence of recurrent breast cancer.

The results of this prospective clinical study were rather compelling. The 10-year survival rates for these women with early-stage breast cancer varied significantly according to the level of Vitamin D in their blood. Survival at 10 years following breast cancer diagnosis was 74 percent, 85 percent, and 85 percent for women with significantly deficient, mildly deficient, and normal Vitamin D levels, respectively. Based upon the analysis of all of the data from this study, breast cancer patients with a significant deficiency of Vitamin D were observed to be almost twice as likely (71 percent increased risk) to experience a recurrence of their breast cancer, and they were 60 percent more likely to die, when compared to the patients who had normal levels of Vitamin D in their blood.

Although this clinical study included relatively few patients, it does, nonetheless, raise the possibility that a significant deficiency of Vitamin D may be associated with a worse prognosis in patients with early-stage breast cancer. Another related finding in this study was that very low levels of Vitamin D also appeared to be associated with breast tumors with more aggressive features when examined under the microscope, which is consistent with other studies that have suggested a link between “high grade” breast tumors and decreased blood levels of Vitamin D. At the same time, as I have already mentioned, the available data regarding Vitamin D levels (and the use of Vitamin D supplements) has not been consistent, and other clinical studies have failed to identify a link between Vitamin D and breast cancer risk. There is also some experimental data available suggesting that very high levels of Vitamin D in the blood may also be associated with poorer outcomes in women with breast cancer (similar findings have also been reported for excessive Vitamin D levels and cardiovascular disease outcomes). Taken together, the data from these various studies strongly suggest that there may be a fairly narrow “optimal range” of Vitamin D levels in the blood that are associated with a decreased risk of breast cancer, a decreased risk of breast cancer recurrence (and death), and a decreased risk of cardiovascular disease; and that excessively high or low levels of this vitamin may have adverse health effects in these areas.

The next obvious step is to conduct larger prospective clinical research trials that secretly randomize patient volunteers to receive various doses of Vitamin D, versus placebo (sugar) pills. There are several such studies already underway (or about to start), involving both cancer patients and patients without cancers. However, it will likely take another 10 years for mature data to emerge from these ongoing studies. Meanwhile, my advice is to eat a healthy and well-balanced diet. If you are a breast or prostate or colorectal cancer survivor, or if you have one or more risk factors for these cancers (or for cardiovascular disease), then you may also want to ask your physician to measure the level of active Vitamin D in your blood. If you are significantly deficient in Vitamin D, then your physician might consider the possibility of Vitamin D supplementation in conjunction with careful serial monitoring of your Vitamin D levels.
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Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity.
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One of the most significant concerns of breast cancer patients is the rate at which the cancer is likely to spread. If the rate and aggressiveness with which the cancer will spread cab be determined, the aggressiveness of the chemo treatment can also be determined. Patients with a type of cancer that is less likely to spread need not be treated as aggressively as the ones with cancer that has a tendency to spread rapidly.

Breast cancer is a disease that takes a physical and emotional toll on the patient. The violent effects of chemo on the body disturbs even the strongest of individuals. Therefore, if the strength of the chemo treatment that must be administered can be determined it will be of great help to several women suffering from this devastating disease.

As a result of recent studies, researchers have been able to discover how to determine, with a certain level of accuracy, the rate at which the breast cancer cells in a particular patient is likely to spread. This is groundbreaking research because as of now there is no reliable method by which physicians can predict what cancers will spread and how rapidly they will. This makes it very difficult to determine which patients should receive aggressive chemo and which ones need not.

For patients who have been recently diagnosed with breast cancer, there is no hundred percent accurate way of predicting whether the cancer cells will return with a vengeance even after they finish treatment. If doctors are able to identify those patients who need especially aggressive chemo sessions because their cancer cells have a propensity to spread rapidly and aggressively, the right treatment can be administered at the right time to save lives. At the same time, unnecessary treatments and hardships can also be avoided by patients who do no particularly need aggressive chemo courses.

The researchers studied a group of women with cancer that had not spread to their lymph nodes and who had not received any chemo or hormonal therapy. The results that were gathered from them were then used to analyze the tumor cells and identify the specific markers that predict relapse of cancer. Studying how these genes travel give researchers a fairly accurate method of predicting what type of cancer they are dealing with, whether the cancer cells are likely to return in future and whether it will spread aggressively.

The results of the study give patients more options to decide on how they need to approach the disease.

Alex White is a free lance writer and a health & fitness expert who has been associated with several health care providers across various specialties. Through his articles, Alex White wishes to inform and educate public about Breast Cancer which will benefit those who are looking for resourceful information regarding health.

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